Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products
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Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.
Choline kinase, responsible for the phosphorylation of choline to phosphocholine as the first step of the CDP-choline pathway for the biosynthesis of phosphatidylcholine, has been recognized as a new target for anticancer therapy. Crystal structures of human choline kinase in its apo, ADP and phosphocholine-bound complexes, respectively, reveal the molecular details of the substrate binding sit...
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Infections of Herpes simplex virus type 1 (HSV1) are associated with oral-facial infections, skin infections, and genital infections. During the past decade, potent agents against herpes virus infections have been found. The action of these agents is based on the difference between viral thymidine kinase (TK) and human TK. Thymidine kinase (TK, EC 2.7.1.21) is the key enzyme in the pyrimidine s...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-40558-x